insipid Diabetes

It is a disease where there is a Hormone deficiency Antidiuretica HAD (also well-known as vasopresina synthesized by the neurohipófisis) or a lack of answer to her by the white organ (the kidneys) there the action of the HAD is the one of reabsorción of water according to the necessity, its deficiency produces one poliuria severe (they tinkle much) with great flowed losses of and the production of tinkles of low density and polidipsia (they take much water) therefore, dehydrates.
Then type of Insipid Diabetes are two:

A. of synthesis or secretion at level of the hipotalámico or hipofisario (central insipid diabetes) in which is no sufficient amount of this hormone available, most of the cases is primary

B. of answer to the HAD of the renales túbulos (nefrogénica insipid diabetes) is a disorder in which the kidney is insensible to the hormone (that in this case if there is but the kidney does not respond) In general is secondary to pielonefritis, IRC, hipercalcemia, hipokalemia, hiperadrenocorticismo, hipertiroidismo, hepática insufficiency and piómetra.

Sintomatologia main in both cases is:

* PU/PD (they take much water and they tinkle much)
* Nocturia (tinkles at night, is that they produce much tinkles! their kidneys do not concentrate)
* Urinary Incontinencia
* thinning
* Central neurological signs (hipotalámica-hipofisaria secondary central diabetes to neoplasia is visual deficits, incoordinación, disorientation and convulsions).
* Other clinical signs in the acquired nefrogénica diabetes will be according to the primary pathology that produces it.

The treatment of this disease is made using acetate of desmopressin (DDAVP), that is a replacement for the antidiurética hormone. It is administered of injectable, intranasal way or in the conjuntiva (gotitas inside the eyes). He is quite effective, but he is something expensive. Some dogs respond to the therapy with other medications, including the diurética of chlorpropamide and chlorothiazide.
The prognosis for this condition varies with the underlying cause: in the primary central insipid diabetes it is good with the suitable treatment, without him is dehydration risk.
The secondary power station is very serious in cerebral and variable case of neoplasia according to trauma of the SNC.
in the nefrogénica secondary it depends on the cause that produces them.

Author: MV Adelaida A. Goldman
www.mascotia.com/oncologia

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